David Holtzman, MD

Washington University in St. Louis

David Holtzman is Professor and Chair of Neurology, scientific director of the Hope Center for Neurological Disorders, and Associate Director of the Knight ADRC at Washington University. Some of his lab’s accomplishments include showing in part how apoE4 contributes to AD, development of a method to measure protein metabolism in the CNS, development of CSF biomarkers for AD, demonstration of how synaptic/neuronal activity and sleep affect amyloid-β (Aβ) and tau levels dynamically in vivo acutely and chronically, and development of an anti-Aβ antibody in a phase 3 trial and an anti-tau antibody in phase 2 clinical trial for AD.