Presidential Symposium: Dominantly Inherited and Late-Onset Alzheimer's Disease: Genetics, Biomarkers, Timecourse, and Treatments

Date/Time: Sunday, October 13, 2019 - 5:15 AM – 7:30 AM
Level: Plenary Session
Room: Majestic D
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Alzheimer’s disease (AD) is the most common cause of dementia. Age and genetics are the 2 most important risk factors. There have been tremendous advances in our understanding of the key molecules and genes that contribute to the pathogenesis of both dominantly inherited as well as late onset-Alzheimer’s disease. In this symposium, the genetics that underlie both forms of the disease will be reviewed and the latest advances in fluid and neuroimaging related biomarkers will be described. The biomarkers, pathology, and clinical features that characterize both forms of AD will be compared. AD pathological changes begin to occur in the brain about 20 years prior to symptom onset in both dominantly inherited and late-onset AD with many similarities and a few differences. These changes have facilitated the design of novel prevention trials in dominantly inherited AD that will be described and discussed.


  • To understand the clinical similarities and differences between early and late onset AD.
    To understand the biomarker and pathological differences between early and late-onset AD.
    To understand the genetic differences between early and late-onset AD.