Dementia and Aging
Date/Time: Sunday, October 13, 2019 - 3:30 PM – 5:30 PM
Level: Special Interest Group
Room: Landmark 4
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Although Alzheimer and related dementias of aging have signature, misfolded proteins that distinguish the pathologic hallmarks of the diseases there remain no disease modifying therapies for most. Increasingly, it is recognized that there are multiple potential modulators of the disease expression that may hold promise as therapeutic targets. During this session the presenters will explore how the study of vascular mechanisms, sleep and genetic-proteomic pathway analyses studies of richly phenotyped populations are identifying important contributors to disease risk and expression. These modulators will be discussed in relation to how they affect amyloid and tau as well as the clinical expression of the disease.
Identify the role of sleep in the AD pathology and progression.
Understand the role of brain imaging in discriminating vascular and neurodegenerative contributors to white matter hyperintensities.
Assess the ways that genetic and -omic studies in AD can identify critical pathways of disease progression.