Advances in Regenerative Medicine: Cellular Memory Systems in Brain Repair
Date/Time: Monday, October 14, 2019 - 8:45 AM – 10:45 AM
Level: Plenary Session
Room: Majestic D
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Recovery after acute brain injury involves adaptation, plasticity and change in spared neural circuits. The mechanisms of plasticity in the brain after injuries such as stroke and head trauma are not well defined, and represent a significant unmet need in neurology. Recent evidence indicates that the cellular mechanisms that mediate synaptic plasticity in learning and memory formation may play a role in neural repair and recovery in stroke and TBI. These provide drug targets for clinical trial in these two diseases, with several underway at present. This symposium will discuss cellular systems involved in learning and memory and how these have been identified as having roles in recovery in stroke and TBI. Dr. Alcino Silva will review molecular memory systems, their common signaling pathways and effects and how these relate to neurodevelopmental and adult neurological diseases. Dr. S. Thomas Carmichael will review three molecular systems originally identified in memory formation, which have been now also shown to play a role in stroke and TBI recovery: CREB, CCR5 and tonic GABA signaling. Dr. Mark Tuszynski will describe molecular and cellular changes that underlie learning in motor and premotor cortex and how these changes can be targeted for therapies in brain injury. Dr. Nicole Calakos will discuss mechanism of synaptic plasticity in the striatum and how these influence habit behaviors and lead to disorders, such as obsessive compulsive disease.
Understand the normal process of recovery after stroke.
Understand the mechanisms of learning and memory in the brain.
Identify mechanisms in the brain that lead to improved recovery after stroke.